Cryptococcus neoformans

Cryptococcus neoformans - Wikipedi

Cryptococcus neoformans - WikiSkript

  1. imal pulmonary infection that is... The primary pulmonary infection can be.
  2. neoformans is an encapsulated, environmental yeast. Cryptococcus neoformans is a round or oval yeast measuring 4-6 µm in diameter, surrounded by a capsule that can be up to 30 µm thick. Spherical fungus which reproduces by budding at any point on the surface, sometimes producing several buds simultaneously at various points
  3. The Cryptococcus neoformans var. neoformans strain B-3501A (serotype D) nuclear genome was sequenced by Stanford University using WGS sequencing. They also end-sequenced BAC clones from a B-3501A BAC library provided by Dr. Jim Kronstad , University of British Columbia
  4. Cryptococcus neoformans ist eine bekapselte Hefe (Sprosspilz) aus der Gattung Cryptococcus, die fakultativ pathogen ist. Der Erreger vermehrt sich asexuell durch Sprossung , also durch Herauswachsen einer Tochterzelle aus der Mutterzelle
  5. Cryptococcus neoformans jest znany jako przedstawiciel drożdży podstawkowych, podczas gdy jego teleomorfa opisywana była pod nazwą Filobasidiella neoformans. Władysław Wojewoda w 2003 r. nadał temu gatunkowi nazwę polską nitkopodstawkówka wodna, ale dla synonimu Filobasidiella neoformans Kwon-Chung [4]

Two Cryptococcus species are pathogenic in humans: C. neoformans (serogroups A and D) and C. gattii (serogroups B and C). C. neoformans variety grubii corresponds to serogroup A and C. neoformans variety neoformans is serogoup D ( Table 1) ( 24 , 36 ) About Press Copyright Contact us Creators Advertise Developers Terms Privacy Policy & Safety How YouTube works Test new features Press Copyright Contact us Creators. Cryptococcus neoformans is a yeast with a prominent polysaccharide capsule. It is an opportunistic fungal pathogen notoriously known as the most common cause of fungal meningitis (infection and inflammation of the meninges) in immunocompromised patients (such as people with AIDS)

Cryptococcus neoformans is a unicellular budding yeast species that is found in the natural environment like soil, tree hollows, and bird excreta. It mostly affects people in the tropical and sub tropical regions like sub Saharan Africa and South East Asian developing countries, where it is the most common cause of meningitis Cryptococcus neoformans is an encapsulated yeast which can act as an opportunistic pathogen in humans. Cryptococcosis can be particularly dangerous in immunologically compromised patients. Picture credit: CDC/Dr. Leanor Haley. Taxonomy ID 214684 Human cryptococcal infections were traditionally attributed to Cryptococcus neoformans until Cryptococcus gattii was classified as a distinct species by molecular methods in 2002 7 Cryptococcus neoformans - a basidomycetous fungus that has two distinct varieties (C. neoformans var grubii, formerly Type A; and C. neoformans var neoformans, formerly Type D). Cryptococcus gattii (formerly C. neoformans Types B and C) is considered a separate species

Cryptococcus neoformans - an overview ScienceDirect Topic

Cryptococcus neoformans . Agente Infeccioso: Cryptococcus neoformans : Referencia cruzada/ sinónimos: Criptococosis, Torulosis, Blastomicosis europea : Características: Levadura; frecuentemente se observan en gemación y posee una cápsula que al microscopio se observa como un halo blanco alrededor de la levadura Cryptococcus neoformans wear a capsule to defend themselves from our immune system. But our mighty white blood cells are usually too powerful for the tiny fu.. Cryptococcus neoformans is a round or oval yeast measuring 4-6 µm in diameter, surrounded by a capsule that can be up to 30 µm thick. Spherical fungus which reproduces by budding at any point on the surface, sometimes producing several buds simultaneously at various points Cryptococcus neoformans var. neoformans (D), C. neoformans var. gattii (B, C), and C. neoformans var. grubii (A). The validity of C. neoformans var. grubii is still being argued and some authors place serotype A as C. neoformans var. neoformans Serotype AD is still being characterized . This species responds well to the azoles but echinocandins.

Treatment for C. neoformans Infection Fungal Diseases CD

  1. Cryptococcus neoformans-The Environmental Budding Yeast. Posted 11/08/2020. Written by Molecular Biologist Dr. Vibhuti Rana, PhD. Cryptococcus neoformans is a unicellular budding yeast species that is found in the natural environment like soil, tree hollows, and bird excreta. It mostly affects people in the tropical and sub tropical regions like sub Saharan Africa and South East Asian.
  2. CRYPTOCOCCUS NEOFORMANS. Presentation subtitle SEJARAH Sanfelice 1894 : peach juice Italy (Sanfelice, 1894 ) Busse dan Buschke ,1895 : cryptococcosis : chronic ulcer tibia Verse 1914 : cryptococcal meningitis Stoddart dan Cutler 1916 : patologi CNS kapsul polisakarida. Struktur sel Cryptococcus Neoformans (Sumber : Simmer dan Secko, 2009).
  3. Cryptococcus neoformans ist ein hefeähnlicher, bekapselter Pilz mit weltweiter Verbreitung. Die Art ist 1 bis 5 µm groß, rundlich und weist einen haploiden Chromosomensatz auf. Das geschlechtliche bzw. teleomorphe Stadium von Cryptococcus neoformans heißt Filobasidiella neoformans und wurde 1976 durch Kwon-Chung beschrieben.. Cryptococcus neoformans ist der wichtigste Erreger der.
  4. Cryptococcus neoformans è un fungo patogeno opportunista ubiquitario, agente eziologico della criptococcosi.. È presente sia in piante che animali, e si ritrova facilmente nel terreno arricchito da feci di piccione (var. neoformans) o nell'humus arricchito di foglie e rami di Eucalyptus camaldulensis (var. gatti

Cryptococcus neoformans. Origem: Wikipédia, a enciclopédia livre. (San Felice) Vuill. Cryptococcus neoformans é uma levedura encapsulada que pode viver tanto em plantas como em animais. O seu teleomorfo é Filobasidiella neoformans, um fungo filamentoso da classe Tremellomycetes Retrouvez toutes les informations sur la cryptococcose sur le site de l'Institut Pasteur. Vaccins, traitements et conseils pour lutter contre la cryptococcose avec la Fondation Pasteur

Pathology Outlines - Cryptococcus

Bệnh do Cryptococcus neoformans. Cryptococcusneoformans thuộc nhóm vi nấm hạt men, đặc trưng bởi sự hiện diện của bao mucopolysaccharide rất dày, bao quanh tế bào. Người khoẻ mạnh cũng như người suy yếu miễn dịch đều có thể bị nhiễm khi hít các bào tử nấm trong không khí. C. Cryptococcus neoformans is a yeast with a prominent polysaccharide capsule. It is an opportunistic fungal pathogen notoriously known as the most common cause of fungal meningitis (infection and inflammation of the meninges) in immunocompromised patients (such as people with AIDS). It reproduces by budding and the single buds are. Cryptococcus neoformans resistance to amphotericin B is very uncommon and, rarely, an explanation for treatment failure. In contrast, fluconazole resistance has been reported with increasing frequency, especially from regions of the world where fluconazole has been used in large populations of HIV-infected persons who are perceived to be at. Cryptococcus neoformans inhabits the soil and is found in bird droppings. It is a relatively common infection in immunocompromised hosts and can cause primary infection. In cytologic specimens, C. neoformans appears as variably sized yeasts, measuring between 4 and 15 μm ( Fig. 36.11). Narrow-based budding is observed Cryptococcus neoformans, an opportunistic fungal pathogen that causes disease predominantly in immuno- compromised patients, is a frequent cause of fatal mycoti

Cryptococcus 1. Cryptococcus neoformans 2. Introduction • Cryptococcus neoformans is an encapsulated yeast and an obligate aerobe that can live in both plants and animal • C. neoformans usually infects the lungs or the central nervous system (the brain and spinal cord), but it can also affect other parts of the body A lumbar puncture is performed and yeast with clear halos is seen with India ink stain. He is started immediately on the appropriate medications. Introduction. Classification. Cryptococcus neoformans. a urease-positive monomorphic encapsulated yeast with 5-10 μm narrow budding. transmitted via inhalation. found in soil and pigeon droppings Cryptococcus neoformans is an encapsulated yeast and an obligate aerobe that can live in both plants and animals. It is often found in bird excrement. It is the causative agent of cryptococcosis (cryptococcal pneumonia and meningitis). Classification Chowdhary A, Córdoba S, et al. Cryptococcus neoformans- Cryptococcus gattii species complex: an internatio nal study of wild-type s usceptibi lity endpoin t distributi ons and epidemio logica

Cryptococcus is a single-celled, oval-shaped yeast that can cause fungal meningitis. C. neoformans is the most common species, but C. gattii has been increasing in prevalence recently in the. Cryptococcus neoformans is a killer. This basidiomycete fungus was first described in 1894, and for many years remained primarily of interest to mycologists and to clinicians observing uncommon. The pathogenic fungus Cryptococcus neoformans is a budding yeast that, in the host lung, switches to an unusual morphotype termed the Titan cell. Titans are large, highly polyploid, have altered cell wall and capsule, and produce haploid daughters. Their size prevents engulfment by phagocytes, yet they are linked to dissemination and altered.

Cryptococcus neoformans exists as two distinct varieties known as variety neoformans and variety gattii (Table 1). Cryptococcus neoformans variety neoformans exists throughout the world and is found frequently in pigeon droppings that have accumulated over time. The concentrations of these organisms are often quite high in old pigeon droppings found in barns, on window ledges, and around the. Heteroresistance to fluconazole (FLC) in Cryptococcus is a transient adaptive resistance which is lost upon release from the drug pressure. It is known that clones heteroresistant to FLC invariably contain disomic chromosomes, but how disomy is formed remains unclear. Previous reports suggested that the aneuploid heteroresistant colonies in Cryptococcus emerge from multinucleated cells. The polysaccharide (PS) capsule of the human pathogenic fungus Cryptococcus neoformans is a beautiful structure, which appears in India Ink preparations as a translucent region ().The capsule is the most important virulence factor of C. neoformans, contributing approximately 25% of the total virulence composite, as estimated from multivariate linear regression analysis to ascertain the. Microbiology - Cryptococcus neoformans & gatti. Opportunistic infection C. neoformans infection in immunocompetent individuals, however, C. gattii infects immunocompetent individuals . Major illness in patients with HIV / AIDS with an estimated 220,000 annual cases of cryptococcal meningitis worldwide (Lancet Infect Dis 2017;17:873) Pulmonary disease can be subacute and indolen

Find proteins for J9VYP5 (Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487) Cryptococcosis. Cryptococcosis also called as Torulosis is a subacute or chronic fungal infection caused by Cryptococcus neoformans. It leads to compications such as fatal meningoencephalitis. It is an opportunistic infection in HIV-infected patients. The PPT discuss on the morphology of the fungus, pathogenesis, laboratory diagnosis and treatment Cryptococcus neoformans is an encapsulated yeast and an obligate aerobe that can live in both plants and animals. Its teleomorph is Filobasidiella neoformans, a filamentous fungus belonging to the class Tremellomycetes. It is often found in bird excrement. Cryptococcus neoformans is an encapsulated fungal organism and it can cause disease in. Cryptococcus neoformans var. grubii is a major human pathogen responsible for deadly meningoencephalitis in immunocompromised patients. Here, we report the sequencing and annotation of its genome. Evidence for extensive intron splicing, antisense transcription, non-coding RNAs, and alternative polyadenylation indicates the potential for highly intricate regulation of gene expression in this.

What is cryptococcosis? Cryptococcosis is a fungal infection caused by inhaling the fungus Cryptococcus neoformans, which is primarily found in soils enriched with pigeon droppings.In moist or desiccated pigeon dropping, C. neoformans may remain viable for 2 years or longer. Two varieties of C. neoformans exist - neoformans and gattii.C. neoformans var neoformans is the most common variety. Cryptococcosis (Cryptococcus neoformans infectie). Cryptococcosis (Cryptococcus neoformans infectie) wordt ingedeeld onder de systemische (diepe) mycosen, samen met histoplasmosis, aspergillosis, coccidioidomycosis, paracoccidioidomycosis, mucormycosis, blastomycosis, en sporotrichosis.Predisponerende factoren zijn immunosupressie (medicamenteus, HIV), diabetes mellitus, lymfomen, sarcoidose. Cryptococcus neoformans: Taxonomy navigation › Cryptococcus neoformans species complex All lower taxonomy nodes (451) Common name i-Synonym i: Filobasidiella neoformans: Other names i ›ATCC 32045 ›Blastomyces neoformans ›CCRC 20528 ›CCRC:20528 ›Cryptococcus neoformans (San Felice) Vuill. 1901 More. Cryptococcus neoformans (teleomorph: Filobasidiella neoformans) is an opportunistic pathogenic fungus found world-wide. It is soil-born and is associated with avian excrement, especially pigeon droppings. It is the most common cause of fungal meningoencephalitis in individuals with compromised cell-mediated immunity,. The human fungal pathogen Cryptococcus neoformans is characterized by its ability to induce a distinct polysaccharide capsule in response to a number of host-specific environmental stimuli. The induction of capsule is a complex biological process encompassing regulation at multiple steps, including the biosynthesis, transport, and maintenance of the polysaccharide at the cell surface

Cryptococcus neoformans. MATERIAL SAFETY DATA SHEET - INFECTIOUS SUBSTANCES . SECTION I - INFECTIOUS AGENT . NAME: Cryptococcus neoformans . SYNONYM OR CROSS REFERENCE: Cryptococcosis, Torulosis, European blastomycosis . CHARACTERISTICS: Yeast; often budding, surrounded by a wide mucopolysaccharide capsule . SECTION II - HEALTH HAZAR Cryptococcus neoformans là một loại nấm hạt men có khả năng sống cả trong cơ thể thực vật và động vật.Dạng sinh sản vô tính của loài nấm này là Filobasidiella neoformans, một loại nấm dạng sợi thuộc về lớp Tremellomycetes MICROBIOLOGY. Cryptococcus spp.is a basidiomycetous yeast. Polysaccharide capsule and melanin are virulence factors. Two Cryptococcus species are pathogenic in humans: C. neoformans (serogroups A and D) andC. gattii (serogroups B and C). C. neoformans variety grubii corresponds to serogroup A and C. neoformans variety neoformans is serogoup D (24, 36) Cryptococcus spp is a major cause of opportunistic infections in immunocompromised patients, primarily due to Cryptococcus neoformans and Cryptococcus gattii.There are occasional reports of other Cryptococcus species causing invasive human disease. However, their epidemiology and clinical significance are not fully defined. We sought to describe cases with cultures positive for Cryptococcus.

Chang YC, et al. Differences between Cryptococcus neoformans and Cryptococcus gattii in the molecular mechanisms governing utilization of D-amino acids as the sole nitrogen source. PLoS One 10: e0131865, 2015. PubMed: 2613222 The major causes of cryptococcosis are infection by C. neoformans and C. gattii.These two species have several types (serotypes) of different capsular polysaccharides that cause the majority of human cryptococcosis (A, D, and AD for C. neoformans; B and C for C. gattii).The three strains of C. gattii that are most frequently found causing cryptococcosis are designated VGlla, VGllb, and VGllc C neoformans y C gattii son los hongos causantes de esta enfermedad.La infección por C neoformans se observa en todo el mundo. La infección por C gattii ha sido observada principalmente en el noreste del Pacífico de los Estados Unidos, Columbia Británica en Canadá, sudeste de África y Australia. El criptococcus es el hongo más común que causa infecciones graves en todo el mundo

Cryptococcus neoformans- An Overview Mycology Microbe

  1. Pathogenic microorganisms must adapt to changes in their immediate surroundings, including alterations in pH, to survive the shift from the external environment to that of the infected host. In the basidiomycete fungal pathogen Cryptococcus neoformans, these pH changes are primarily sensed by the fungus-specific, alkaline pH-sensing Rim/Pal pathway
  2. クリプトコッカス症(クリプトコッカスしょう、英: cryptococcosis )とはクリプトコッカス属に属する酵母様真菌の感染を原因とする人獣共通感染症。 ヒト、イヌ、ネコなどに感染する。 主にCryptococcus neoformansによる呼吸器症状が認められる。クリプトコッカス属は空気中や土壌、植物などの環境.
  3. Cryptococcus neoformans is an encapsulated yeast. In 1894, Busse, a pathologist, first described the yeast in a paper he presented to the Greifswald Medical Society. Busse isolated the yeast from the tibia of a 31-year-old woman, noted its resistance to sodium hydroxide,.
  4. Cryptococcus neoformans is a fungal pathogen that causes life-threatening infections in immunocompromised individuals. It is surrounded by three concentric structures that separate the cell from the extracellular space: the plasma membrane, the cell wall and the polysaccharide (PS) capsule. Although several studies have revealed the chemical composition of these structures, little is known.
  5. A criptococose é uma doença fúngica causada pelo fungo Cryptococcus neoformans. Nas décadas de 1970 e 1980 era considerada rara, no entanto ganhou importância com o estabelecimento da epidemia de HIV+/AIDS nos anos 1990, e continua tendo grande relevância atualmente. O C. neoformans é uma levedura encapsulada, de distribuição ubíqua, sendo encontrado no solo e em fezes de aves, como.

Cryptococcus Neoformans - Habitat, Epidemiology, Treatment

クリプトコッカス症は,莢膜を有する酵母のCryptococcus neoformansまたはC. gattiiで汚染された土壌の吸入により,罹患する肺感染症または播種性感染症である。症状は肺炎,髄膜炎の症状,または皮膚,骨,内臓の病変である Cryptococcus neoformans is a heavily encapsulated yeast and an obligate aerobe. It is non-dimorphic and has narrow-based budding. It is often found in bird excrement and soil, and thus immunocompromised patients are at risk for opportunistic infection via inhalation and subsequent hematogenous spread

Cryptococcus neoformans genome data and search tip

Cryptococcus neoformans - DocCheck Flexiko

A criptococose, popularmente conhecida como doença do pombo, é uma doença infecciosa causada pelo fungo Cryptococcus neoformans, que pode ser encontrado principalmente nas fezes dos pombos, mas também em frutas, solos, cereais e árvores, por exemplo. A infecção pelo Cryptococcus neoformans é considerada oportunista, isso porque desenvolve-se mais facilmente em pessoas que possuem. 一、前言. 新型隱球菌 (Cryptococcus neoformans) 能引起隱球菌病 (cryptococcosis) 及隱球菌腦膜炎 (cryptococcal meningitis) ,在世界各地均有散發性病例。 新型隱球菌病是一種常見伺機性黴菌感染症,在正常健康成人或是免疫功能低下的病患均可發現,其中大部分病患都具有潛在性疾病,如惡性淋巴瘤、類肉瘤.

Cryptococcus neoformans - Wikipedia, wolna encyklopedi

Cryptococcus neoformans (Cryptococcosis) - Infectious

Introduction: Cryptococcus neoformans is an encapsulated fungal pathogen that causes life-threatening meningoencephalitis in immunocompromised patients. This yeast secretes several potent immunogenic proteins by secretory vesicular mechanisms, suc Cryptococcus neoformans Yeast Worldwide distribution often found in soil contaminated with bird excrement, in particular, pigeon droppings have frequently been implicated. Cryptococcus neoformans is a rapidly growing typically round yeast (5-10µm) capable of producing polysaccharide capsules which often surround the cell. A 1% peptone solution. Cryptococcus neoformans. Overview: Cryptococcus neoformans is an unicellular, encapsulated, non-motile, non-spore-forming, non-lactose fermenting, anaerobic yeast-like fungus that possesses a thick polysaccharide cell wall and causes the infection cryptococcosis (Figure 1).The organism is coccus-shaped and roughly 6 μm (micrometres) to 8 μm in diameter

Cryptococcus neoformans - YouTub

Abstract. In Egypt, the River Red Gum (Eucalyptus camaldulensis) is a well-known tree and is highly appreciated by the rural and urban dwellers.The role of Eucalyptus trees in the ecology of Cryptococcus neoformans is documented worldwide. The aim of this survey was to show the prevalence of C. neoformans during the flowering season of E. camaldulensis at the Delta region in Egypt Cryptococcus neoformans is a yeast-like fungus enclosed by a capsule. It was first identified in nature from samples of peach juice, but has proven to be found more abundantly in soil contaminated with pigeon droppings, eucalyptus trees, decaying wood from living trees, and in goats with pulmonary disease

Cryptococcus neoformans: Properties, Pathogenesis, Lab

Etiqueta: Cryptococcus neoformans. Publicado el 24/11/2019 24/11/2019. Tsunamis y cambios en la etiología de la criptococosis canina y felina. F. Javier Cabañes. F. Javier Cabañes. Grupo de Micología Veterinaria, Departamento de Sanidad y Anatomía Animales, Facultad de Veterinaria, Universitat Autònoma de Barcelona, Bellaterra, España Cryptococcus neoformans is an encapsulated, round-to-oval yeast measuring 4-6 microns with a surrounding polysaccharide capsule ranging in size from 1 to >30 microns when cultivated in the laboratory. In its natural environment, it is smaller and poorly encapsulated (August 2003) When opportunity strikes you may just find Cryptococcus neoformans making the most of it. Cryptococcus neoformans is pathogen. Cryptococcus neoformans is also an opportunist. Over the past 10 years, infections of this pathogen have been on the rise, mostly striking individuals with compromised immune systems [1]. As an emergent disease it has taken advantage of the recent rise in. Pathogen Safety Data Sheet: Infectious Substances - Cryptococcus neoformans SECTION I - INFECTIOUS AGENT NAME: Cryptococcus neoformans SYNONYM OR CROSS REFERENCE: C. neoformans var neoformans, cryptococcosis, cryptococcal infections, cryptococci, torulosis, European blastomycosis 1-3. CHARACTERISTICS: C. neoformans is a spherical yeast, 4-6 µm in diameter, that produces

Cryptococcus neoformans - The Environmental Budding Yeas

Cryptococcus neoformans is a basidiomycetous opportunistic yeast that is widely present in the environment. It causes human cryptococcosis, which mainly affects immunocompromised patients and presents as a meningoencephalitis that is lethal without treatment.Clinical presentation is often diagnosed late because clinical symptoms are initially mild with a subacute to chronic evolution () Cryptococcus neoformans crece en la mayoría de los medios de cultivo empleados en el laboratorio de micología. En agar Sabouraud o en agar extracto de malta, las colonias se desarrollan en 36 a 72 horas a 25-30 °C o a 37 °C. Estas colonias son de color blanco amarillento a crema, y se tornan más oscuras al envejecer Cryptococcosis neoformans (teleomorph Filobasidiella neoformans); Cryptococcus neoformans var. neoformans and Cryptococcus neoformans var. grubii.; Cryptococcus gattii used to be regarded as a third variety of C. neoformans.However, based on differences in biochemical, ecological, epidemiological and molecular characteristics, it is now recognized as a separate specie INTRODUCTION. Cryptococcus neoformans pneumonia and infection outside the central nervous system in immunocompetent and immunocompromised patients will be reviewed here.. The microbiology and epidemiology of C. neoformans infection are presented separately.C. neoformans meningoencephalitis and Cryptococcus gattii infection are also discussed elsewhere. (See Microbiology and epidemiology of.

Gram stain of narrow budding fungal bodies (arrow) whichCryptococcus neoformans - wikidoc

Cryptococcus neoformans is an opportunistic fungi... encapsulated with thick polysaccharide layer with antiphagocytic properties... thick cell wall of neoformans is composed of polysaccharides... common found in pigeon droppings/soil-> enters body via inhalation... urease positive.. El género Cryptococcus incluye muchas especies, de las que solo C. neoformans se considera patógeno humano, aunque existen referencias en la literatura de otras especies (Cryptococcus laurentii y Cryptococcus albidus) que han producido enfermedad en humanos, especialmente en los inmunodeprimidos Cryptococcus neoformans is an encapsulated fungal pathogen causing fatal meningitis in humans. The infection, initiated by inhalation into the lungs, occurs mainly in immunocompromised individuals, but can also occur in healthy individuals. Cryptococcus neoformans is usually found in tissues in the yeast form Palabras clave: Criptococosis; Cryptococcus gattii; Cryptococcus neoformans. Cryptococcosis Abstract Cryptococcosis is an opportunistic fungal infection of worldwide distribution, mainly produced by the complex Cryptococcus neoformans / Cryptococcus gattii, both are widely distributed in nature, primarily affecting immunocompromised patients Cryptococcus neoformans meningoencephalitis is the most frequently encountered manifestation of cryptococcosis. The term meningoencephalitis is more appropriate than meningitis since histopathological examination has demonstrated that the brain parenchyma is almost always involved Cryptococcus neoformans 1. CRYPTOCOCCUS NEOFORMANS Dr.T.V.Rao MDDR.T.V.RAO MD 1 2. CRYPTOCOCCOSISChronic, subacute to acute pulmonary, systemic ormeningitic disease, initiated by the inhalation of thefungus. Primary pulmonary infections have nodiagnostic symptoms and are usually subclinical